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Contraindicated (1)pentobarbital will lower the extent or outcome of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the extent or effect of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Sturdy CYP3A4 inducers might reduce midostaurin con